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A clinical gamma camera-based pinhole collimated system for high resolution small animal SPECT imaging BJMBR
Mejia,J.; Galvis-Alonso,O.Y.; Castro,A.A.de; Braga,J.; Leite,J.P.; Simões,M.V..
The main objective of the present study was to upgrade a clinical gamma camera to obtain high resolution tomographic images of small animal organs. The system is based on a clinical gamma camera to which we have adapted a special-purpose pinhole collimator and a device for positioning and rotating the target based on a computer-controlled step motor. We developed a software tool to reconstruct the target’s three-dimensional distribution of emission from a set of planar projections, based on the maximum likelihood algorithm. We present details on the hardware and software implementation. We imaged phantoms and heart and kidneys of rats. When using pinhole collimators, the spatial resolution and sensitivity of the imaging system depend on parameters such as...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pinhole collimator; SPECT; Small animal organs; Maximum likelihood; Instrumentation; Image processing.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001200004
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Development of radioimmunoconjugate for diagnosis and management of head-and-neck subclinical cancer and colorectal carcinoma BJPS
Benedetto,Raquel; Massicano,Adriana Vidal Fernandes; Silva,Jefferson Jesus; Boas,Cristian Antonio Wieczorek Villas; Mengatti,Jair; Araújo,Elaine Bortoleti de.
ABSTRACT Scientific innovations in diagnostic methods are important drivers of cancer control and prevention. Noninvasive imaging of the epidermal growth factor receptor (EGFR) in head-and-neck squamous, cell carcinoma and colorectal cancer could be valuable to select patients for EGFR-targeted therapy, as well as to monitor the efficacy and occurrence of resistance to immunotherapy. In order to develop the first Brazilian radioimmunoconjugate for diagnosis, Cetuximab has been conjugated to p-SCN-Bn-DTPA chelator and radiolabeled with Indium-111. The conjugation methodology was optimized using different mAb:DTPA molar ratios, time was then reduced for immunoconjugate preparation, besides the protein recovery’ percentage increased after purification (m =...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Radioimmunoconjugate/development; Head and neck cancer/diagnosis; Tumors diagnosis; Cetuximab; SPECT; 111In.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400624
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Hallazgos Morfométricos y Funcionales Acerca de la Ínsula en Población VIH+ con Apatía International Journal of Morphology
Tornese,Elba Beatriz; Mazzoglio y Nabar,Martín Javier.
La corteza insular es uno de los componentes de la zona paralímbica que presenta conexiones con áreas corticales y subcorticales. El estudio en personas viviendo con VIH (PVVIH), donde la apatía es frecuente, la implicó como modulador de respuesta emocional y ejecutiva. El objetivo es describir morfométricamente y funcionalmente la ínsula en relación con estructuras cerebrales corticales y subcorticales en PVVIH con apatía en comparación con controles y con PVVIH sin apatía, a fin de determinar su implicancia. Estudiamos 23 encéfalos de PVVIH de sexo masculino con apatía según evaluaciones neuropsiquiátricas. Se utilizó resonancia magnética (RM) con protocolo cognitivo para cuantificación y tomografía por emisión de fotón único (SPECT) para evaluar la...
Tipo: Journal article Palavras-chave: Ínsula; Apatía; VIH; RM; SPECT.
Ano: 2017 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100044
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Nuclear medicine procedures for the evaluation of male sexual organs: a brief review BABT
Bernardo-Filho,Mario; Santos-Filho,Sebastião David; Fonseca,Adenilson de Souza da; Carter,Kevin; Missailidis,Sotiris.
Sexuality consists of three aspects that are interrelated and inseparable, biological, physiological and social. The biological aspect considers the individual's capability to give and to receive pleasure. In consequence, it covers the functionality of the sexual organs and the physiology of human sexual response cycle. Diagnostic imaging modalities, such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) have been used to evaluate clinical disorders of the male reproductive system. PET and SPECT procedures basically involve the administration of a radiopharmaceutical that has a higher uptake in a specific tumor or tissue. The aim of this brief review is to present some radiopharmaceuticals that have been used in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Male sexual organs; PET; SPECT; Radiopharmaceutical; Sexuality.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700004
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